Research

      With one hand, a special interest in 1,2,5-oxadiazole chemistry is attributed to the construction of high-energy systems incorporating additional nitrogen-oxygen explosophoric fragments.1,2 It is connected with aromaticity and planarity of 1,2,5-oxadiazole subunit resulting in high density of furazan- and furoxan-containing derivatives. Moreover, in contrast to other nitrogen heterocycles furazan and furoxan possess “active” oxygen atoms that are not bonded with hydrogen or carbon atoms and are therefore able to oxidize these atoms in the combustion or explosive degradation processes.
          In other hand, furoxans are attractive objects for the construction of pharmacologically oriented frameworks, because in interaction with thiols, furoxan is revealed and the releasing molecule NO is a universal regulator of cellular metabolism

            Aldol-Croton condensation of imidazole[4,5-e]thiazolo[3,2-b]triazines 1 with isatines using alkaline catalysis with 40% aqueous KOH solution was studied. In the process of selecting optimal conditions for its flow, it was found that, depending on the amount of alkali, one of two regioisomeric oxoindolidene derivatives of imidazo[4,5-e]thiazolo[3,2-b]triazines or imidazo[4,5-e]thiazolo[2,3-c]triazines 2 and 3 — products of not only condensation but also rearrangement of the thiazolotriazine system is selectively formed. This technique has proved effective for the synthesis of a wide range of isatinylidene derivatives with different substituents in both the tricyclic and indole fragment.
         